PRTN3

May play a role in neutrophil transendothelial migration, probably when associated with CD177.
Full Name
proteinase 3
Function
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246).
By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369).
May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).
Biological Process
Antimicrobial humoral responseTAS:Reactome
Cell-cell junction maintenanceManual Assertion Based On ExperimentIMP:UniProtKB
Collagen catabolic processIEA:UniProtKB-KW
Mature conventional dendritic cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of phagocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Neutrophil extravasationManual Assertion Based On ExperimentIMP:UniProtKB
PhagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
ProteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasmic granule
Secreted
Cell membrane
Membrane raft
Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils (PubMed:2033050, PubMed:3198760, PubMed:7897245, PubMed:18462208).
Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration (PubMed:22266279, PubMed:28240246).
Following secretion tethered to the cell membrane by CD177 (PubMed:18462208, PubMed:22266279).
Involvement in disease
Is the major autoantigen in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (Wegener's granulomatosis) (PubMed:2377228, PubMed:2679910). This complex, systemic disease is characterized by granulomatous inflammation with necrotizing lesions in the respiratory tract, glomerulonephritis, vasculitis, and anti-neutrophil cytoplasmatic autoantibodies detected in patient sera (PubMed:2377228, PubMed:2679910). PRTN3 causes emphysema when administered by tracheal insufflation to hamsters (PubMed:3198760).
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Anti-PRTN3 antibodies

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Recombinant Mouse Anti-PRTN3 Antibody (CBHb234) (CBMAB-Hb908-LY)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb234
Application*: FC, IHC-F, FuncS, Immuno assays, IF, IP, IHC-P, WB
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (WGM2) (CBMAB-P3090-YC)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: WGM2
Application*: WB, E, P, C, FN, F, I
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (13B647) (CBMAB-P3082-YC)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 13B647
Application*: E, WB
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (CBFYM-3080) (CBMAB-M3276-FY)

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Target: PRTN3
Host: Mouse
Specificity: Human
Clone: CBFYM-3080
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (2F10) (CBMAB-A7105-LY)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2F10
Application*: E, E
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (CBFYA-0152) (CBMAB-X0219-FY)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0152
Application*: F, C, FN, IA, IF, IP, P, WB
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (PR3G-2) (CBMAB-P3089-YC)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: PR3G-2
Application*: WB, C, F
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (MCPR3-2) (CBMAB-P3088-YC)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MCPR3-2
Application*: WB, F, IC, IF
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (3B4) (CBMAB-P3087-YC)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3B4
Application*: WB
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (2F1) (CBMAB-P3086-YC)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2F1
Application*: E
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (1F11) (CBMAB-P3085-YC)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1F11
Application*: E
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (1D10) (CBMAB-P3084-YC)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D10
Application*: P
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (1B10) (CBMAB-P3083-YC)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B10
Application*: WB, E
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (CBFYM-3081) (CBMAB-M3277-FY)

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Target: PRTN3
Host: Mouse
Specificity: Rat
Clone: CBFYM-3081
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (CBT1060) (V2LY-0625-LY3069)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1060
Application*: WB, E
Datasheet SDS

Mouse Anti-PRTN3 Recombinant Antibody (CBT3445) (V2LY-0625-LY2300)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3445
Application*: WB
Datasheet SDS

Recombinant Mouse Anti-PRTN3 Antibody (CBHb235) (CBMAB-Hb907-LY)

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Target: PRTN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb235
Application*: FC, FuncS, Immuno assays, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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