PRTN3
May play a role in neutrophil transendothelial migration, probably when associated with CD177.
Function
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246).
By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369).
May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).
Biological Process
Antimicrobial humoral responseTAS:Reactome
Cell-cell junction maintenanceManual Assertion Based On ExperimentIMP:UniProtKB
Collagen catabolic processIEA:UniProtKB-KW
Mature conventional dendritic cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of phagocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Neutrophil extravasationManual Assertion Based On ExperimentIMP:UniProtKB
PhagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
ProteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasmic granule
Secreted
Cell membrane
Membrane raft
Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils (PubMed:2033050, PubMed:3198760, PubMed:7897245, PubMed:18462208).
Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration (PubMed:22266279, PubMed:28240246).
Following secretion tethered to the cell membrane by CD177 (PubMed:18462208, PubMed:22266279).
Involvement in disease
Is the major autoantigen in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (Wegener's granulomatosis) (PubMed:2377228, PubMed:2679910). This complex, systemic disease is characterized by granulomatous inflammation with necrotizing lesions in the respiratory tract, glomerulonephritis, vasculitis, and anti-neutrophil cytoplasmatic autoantibodies detected in patient sera (PubMed:2377228, PubMed:2679910). PRTN3 causes emphysema when administered by tracheal insufflation to hamsters (PubMed:3198760).
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Datasheet