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Mouse Anti-PSAT1 Antibody (10BA24) (CBMAB-1506CQ)

This product is a mouse antibody that recognizes PSAT1. The antibody 10BA24 can be used for immunoassay techniques such as: ELISA, IHC-P, IHC, MA, WB.
See all PSAT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
10BA24
Antibody Isotype
IgG1
Application
ELISA, IHC-P, IHC, MA, WB

Basic Information

Immunogen
Recombinant full length protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PSAT1
Introduction
This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine aminotransferase and decreased expression may be associated with schizophrenia. It catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. Diseases associated with PSAT1 include Phosphoserine Aminotransferase Deficiency and Neu-Laxova Syndrome 2. Among its related pathways are Metabolism and One carbon pool by folate.
Entrez Gene ID
29968
UniProt ID
Q9Y617
Alternative Names
PSA; EPIP; NLS2; PSAT; PSATD
Function
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
Biological Process
L-serine biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Pyridoxine biosynthetic process1 PublicationNAS:UniProtKB
Cellular Location
Phosphoserine aminotransferase deficiency (PSATD):
Characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.
Neu-Laxova syndrome 2 (NLS2):
A form of Neu-Laxova syndrome, a lethal, autosomal recessive multiple malformation syndrome characterized by ichthyosis, marked intrauterine growth restriction, microcephaly, short neck, limb deformities, hypoplastic lungs, edema, and central nervous system anomalies. These include lissencephaly, cerebellar hypoplasia and/or abnormal/agenesis of the corpus callosum. Abnormal facial features include severe proptosis with ectropion, hypertelorism, micrognathia, flattened nose, and malformed ears.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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