Mouse Anti-PSC Recombinant Antibody (6E8) (CBMAB-0274-CN)

Name: Mouse Anti-PSC Recombinant Antibody (6E8)
SKU: CBMAB-0274-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6E8

Application

ELISA

Specificity

Common fruit fly

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Psc

Introduction

Posterior sex combs was originally identified as a member of the Polycomb group of genes that regulate gene expression through epigenetic marks.

Entrez Gene ID

36431

UniProt ID

P35820

Alternative Names

49Ea; CG3886; D-Bmi; Dmel\CG3886; dPSC; l(2)49Ea; l(2)Psc; l(2)vr14; psc; PSC; Psc1; Su(z)2-C; vr14

Function

Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (BX-C) complexes, and hence for the maintenance of segmental determination.

Biological Process

Anterior/posterior axis specificationManual Assertion Based On ExperimentIMP:UniProtKB
Chromatin remodelingManual Assertion Based On ExperimentIDA:FlyBase
Heterochromatin assemblyManual Assertion Based On ExperimentIDA:FlyBase
Histone H2A-K119 monoubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:FlyBase
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Syncytial blastoderm mitotic cell cycleManual Assertion Based On ExperimentIMP:FlyBase
Ventral cord developmentManual Assertion Based On ExperimentHMP:FlyBase

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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