PSC

Posterior sex combs was originally identified as a member of the Polycomb group of genes that regulate gene expression through epigenetic marks.

Full Name

Psc

Function

Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (BX-C) complexes, and hence for the maintenance of segmental determination.

Biological Process

Anterior/posterior axis specificationManual Assertion Based On ExperimentIMP:UniProtKB
Chromatin remodelingManual Assertion Based On ExperimentIDA:FlyBase
Heterochromatin assemblyManual Assertion Based On ExperimentIDA:FlyBase
Histone H2A-K119 monoubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:FlyBase
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Syncytial blastoderm mitotic cell cycleManual Assertion Based On ExperimentIMP:FlyBase
Ventral cord developmentManual Assertion Based On ExperimentHMP:FlyBase

Cellular Location

Nucleus