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Mouse Anti-PSMD4 Recombinant Antibody (p32(26S-161)) (CBMAB-2126CQ)

This product is a mouse monoclonal antibody that recognizes PSMD4. The antibody p32(26S-161) can be used for immunoassay techniques such as: IHC-Fr, IF, WB.
See all PSMD4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Frog
Clone
p32(26S-161)
Antibody Isotype
IgG1
Application
IHC-Fr, IF, WB

Basic Information

Specificity
Human, Rat, Frog
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PSMD4
Introduction
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. Diseases associated with PSMD4 include Angelman Syndrome and Spherocytosis, Type 5. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6.
Entrez Gene ID
Human5710
Rat83499
Frog407871
UniProt ID
HumanP55036
RatO88321
FrogQ6NVQ2
Alternative Names
AF; ASF; S5A; AF-1; MCB1; Rpn10; pUB-R5
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.
Biological Process
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
cytosol
nucleoplasm
nucleus
proteasome accessory complex
proteasome complex
proteasome regulatory particle, base subcomplex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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