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Mouse Anti-PSMD8 Recombinant Antibody (P31-27) (CBMAB-2124CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
P31-27
Antibody Isotype
IgG
Application
IHC, WB

Basic Information

Immunogen
Recombinant Rpn12 protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proteasome 26S Subunit, Non-ATPase 8
Introduction
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6.
Entrez Gene ID
5714
UniProt ID
P48556
Alternative Names
C76433; AA407360; AL033291; AL033322; AL033323; 6720456J22Rik; 26S proteasome non-ATPase regulatory subunit 8; 26S proteasome; egulatory subunit RPN12; 26S proteasome regulatory subunit S14; proteasome 26S non-ATPase subunit 8; S14; p31; HIP6; HYPF; Nin1p; Rpn12; HEL-S-91n; 26S proteasome non-ATPase regulatory subunit 8; 26S proteasome regulatory subunit RPN12; 26S proteasome regulatory subunit S14; 26S proteasome regulatory subunit p31; epididymis secretory sperm binding protein Li 91n; proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Biological Process
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
cytosol
nucleoplasm
nucleus
proteasome accessory complex
proteasome complex
proteasome regulatory particle
proteasome regulatory particle, lid subcomplex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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