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Mouse Anti-PSME3 Recombinant Antibody (CBYC-P726) (CBMAB-P3257-YC)

Provided herein is a Mouse monoclonal antibody against Human Proteasome Activator Subunit 3. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PSME3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Fruit fly, Mouse, Pig
Clone
CBYC-P726
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Specificity
Human, Fruit fly, Mouse, Pig
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proteasome Activator Subunit 3
Introduction
PSME3 (Proteasome Activator Subunit 3) is a protein coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology annotations related to this gene include identical protein binding and MDM2/MDM4 family protein binding. An important paralog of the gene is PSME1.
Entrez Gene ID
Human10197
Mouse19192
Pig397625
UniProt ID
HumanP61289
MouseP61290
PigP61291
Alternative Names
AA410043; AU020960; REG-GAMMA; REGgamma; Ki; PA28gamma; PA28-gamma; pa28g; PA28G; HEL-S-283
Function
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).
Biological Process
Apoptotic processIEA:UniProtKB-KW
Cell cycleIEA:UniProtKB-KW
Negative regulation of extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIBA:GO_Central
Regulation of proteasomal protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase.
PTM
Phosphorylated by MAP3K3 (By similarity).
Phosphorylation at Ser-247 promotes its association with CCAR2.
Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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