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Mouse Anti-PSMG2 Recombinant Antibody (1E3) (CBMAB-P3266-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1E3
Antibody Isotype
IgG2b
Application
WB, IF

Basic Information

Immunogen
Full length human recombinant protein of human PSMG2 (NP_064617) produced in E. coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proteasome assembly chaperone 2
Introduction
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Entrez Gene ID
56984
UniProt ID
Q969U7
Alternative Names
TNFSF5IP1; HsT1707; PAC2; CLAST3; MDS003; HCCA3
Function
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Biological Process
Chaperone-mediated protein complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Mitotic spindle assembly checkpoint signalingIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Proteasome assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Proteasome-associated autoinflammatory syndrome 4 (PRAAS4):
An autosomal recessive, autoinflammatory disorder characterized by panniculitis and erythematous skin lesions apparent in early infancy. Additional features include hepatosplenomegaly, lymphadenopathy, autoimmune hemolytic anemia, fever, generalized lipodystrophy, myositis, joint contractures, and mild motor and speech delay.
PTM
Degraded by the proteasome upon completion of 20S proteasome maturation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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