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PSMG2

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.

Full Name

Proteasome assembly chaperone 2

Function

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.

Biological Process

Chaperone-mediated protein complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Mitotic spindle assembly checkpoint signalingIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Proteasome assemblyManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Involvement in disease

Proteasome-associated autoinflammatory syndrome 4 (PRAAS4):
An autosomal recessive, autoinflammatory disorder characterized by panniculitis and erythematous skin lesions apparent in early infancy. Additional features include hepatosplenomegaly, lymphadenopathy, autoimmune hemolytic anemia, fever, generalized lipodystrophy, myositis, joint contractures, and mild motor and speech delay.

PTM

Degraded by the proteasome upon completion of 20S proteasome maturation.

Anti-PSMG2 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-PSMG2 Recombinant Antibody (3F1) (CBMAB-P3269-YC)

SDS

Target: PSMG2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3F1

Application*: IH, WB

Mouse Anti-PSMG2 Recombinant Antibody (2E12) (CBMAB-P3268-YC)

SDS

Target: PSMG2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 2E12

Application*: IH

Mouse Anti-PSMG2 Recombinant Antibody (1E3) (CBMAB-P3266-YC)

SDS

Target: PSMG2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1E3

Application*: WB, IF

Mouse Anti-PSMG2 Recombinant Antibody (CBYJT-1609) (CBMAB-T0653-YJ)

SDS

Target: PSMG2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-1609

Application*: WB

Mouse Anti-PSMG2 Recombinant Antibody (CBYJT-1608) (CBMAB-T0652-YJ)

SDS

Target: PSMG2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-1608

Application*: IC, IF, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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