PSMG2

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Full Name
Proteasome assembly chaperone 2
Function
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Biological Process
Chaperone-mediated protein complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Mitotic spindle assembly checkpoint signalingIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Proteasome assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Proteasome-associated autoinflammatory syndrome 4 (PRAAS4):
An autosomal recessive, autoinflammatory disorder characterized by panniculitis and erythematous skin lesions apparent in early infancy. Additional features include hepatosplenomegaly, lymphadenopathy, autoimmune hemolytic anemia, fever, generalized lipodystrophy, myositis, joint contractures, and mild motor and speech delay.
PTM
Degraded by the proteasome upon completion of 20S proteasome maturation.
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Anti-PSMG2 antibodies

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Mouse Anti-PSMG2 Recombinant Antibody (3F1) (CBMAB-P3269-YC)

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Target: PSMG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3F1
Application*: IH, WB
Datasheet SDS

Mouse Anti-PSMG2 Recombinant Antibody (2E12) (CBMAB-P3268-YC)

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Target: PSMG2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2E12
Application*: IH
Datasheet SDS

Mouse Anti-PSMG2 Recombinant Antibody (1E3) (CBMAB-P3266-YC)

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Target: PSMG2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1E3
Application*: WB, IF
Datasheet SDS

Mouse Anti-PSMG2 Recombinant Antibody (CBYJT-1609) (CBMAB-T0653-YJ)

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Target: PSMG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1609
Application*: WB
Datasheet SDS

Mouse Anti-PSMG2 Recombinant Antibody (CBYJT-1608) (CBMAB-T0652-YJ)

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Target: PSMG2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-1608
Application*: IC, IF, WB
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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