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PSMG2

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.

Full Name

Proteasome assembly chaperone 2

Function

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.

Biological Process

Chaperone-mediated protein complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Mitotic spindle assembly checkpoint signalingIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Proteasome assemblyManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Involvement in disease

Proteasome-associated autoinflammatory syndrome 4 (PRAAS4):
An autosomal recessive, autoinflammatory disorder characterized by panniculitis and erythematous skin lesions apparent in early infancy. Additional features include hepatosplenomegaly, lymphadenopathy, autoimmune hemolytic anemia, fever, generalized lipodystrophy, myositis, joint contractures, and mild motor and speech delay.

PTM

Degraded by the proteasome upon completion of 20S proteasome maturation.

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Anti-PSMG2 antibodies

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Mouse Anti-PSMG2 Recombinant Antibody (3F1) (CBMAB-P3269-YC)

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Target: PSMG2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3F1

Application*: IH, WB

Mouse Anti-PSMG2 Recombinant Antibody (2E12) (CBMAB-P3268-YC)

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Target: PSMG2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 2E12

Application*: IH

Mouse Anti-PSMG2 Recombinant Antibody (1E3) (CBMAB-P3266-YC)

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Target: PSMG2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1E3

Application*: WB, IF

Mouse Anti-PSMG2 Recombinant Antibody (CBYJT-1609) (CBMAB-T0653-YJ)

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Target: PSMG2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-1609

Application*: WB

Mouse Anti-PSMG2 Recombinant Antibody (CBYJT-1608) (CBMAB-T0652-YJ)

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Target: PSMG2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-1608

Application*: IC, IF, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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