Mouse Anti-PTH Recombinant Antibody (13B654) (CBMAB-P3349-YC)

PTH

PTH is a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness.

PTH1

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.

Activation of phospholipase C activityManual Assertion Based On ExperimentIMP:CAFA
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Bone mineralizationIEA:Ensembl
Bone resorption1 PublicationNAS:UniProtKB
cAMP metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell signalingManual Assertion Based On ExperimentIBA:GO_Central
Cellular calcium ion homeostasisIEA:Ensembl
Cellular macromolecule biosynthetic processManual Assertion Based On ExperimentIDA:MGI
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Homeostasis of number of cells within a tissueIEA:Ensembl
Hormone-mediated apoptotic signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Magnesium ion homeostasisIEA:Ensembl
Negative regulation of apoptotic process in bone marrow cellIEA:Ensembl
Negative regulation of bone mineralization involved in bone maturationIEA:Ensembl
Negative regulation of chondrocyte differentiationIEA:Ensembl
Negative regulation of gene expressionManual Assertion Based On ExperimentIDA:GO_Central
Phosphate ion homeostasisIEA:Ensembl
Positive regulation of bone mineralizationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell proliferation in bone marrowIEA:Ensembl
Positive regulation of glucose importManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of glycogen biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of inositol phosphate biosynthetic processManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of osteoclast proliferationIEA:Ensembl
Positive regulation of signal transductionIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Regulation of gene expressionManual Assertion Based On ExperimentIDA:MGI
Response to cadmium ionIEA:Ensembl
Response to ethanolIEA:Ensembl
Response to fibroblast growth factorIEA:Ensembl
Response to lead ionIEA:Ensembl
Response to parathyroid hormoneIEA:Ensembl
Response to vitamin DIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Rho protein signal transductionIEA:Ensembl
Sskeletal system developmentManual Assertion Based On ExperimentTAS:ProtInc
Transcription by RNA polymerase IIIEA:Ensembl

Secreted

Hypoparathyroidism, familial isolated, 1 (FIH1):
A form of hypoparathyroidism, a disorder characterized by hypocalcemia and hyperphosphatemia due to a deficiency of parathyroid hormone. Clinical features include seizures, tetany and cramps. FIH1 inheritance can be autosomal dominant or recessive.