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Mouse Anti-PTPMT1 Recombinant Antibody (CBYC-P776) (CBMAB-P3408-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein tyrosine phosphatase, mitochondrial 1. The antibody can be used for immunoassay techniques, such as ELISA, IHC-P, WB.
See all PTPMT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P776
Antibody Isotype
IgG1
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Tris-HCl, pH 7.0, 0.02% proclin 300
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein tyrosine phosphatase, mitochondrial 1
Introduction
PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues.
Entrez Gene ID
114971
UniProt ID
Q8WUK0
Alternative Names
DUSP23; MOSP; PLIP; PNAS-129
Function
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity).
PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity).
Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity).
Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity).
Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).
May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (PubMed:24709986).
Biological Process
Cardiolipin biosynthetic processISS:UniProtKB
Protein dephosphorylationIEA:InterPro
Regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIGI:UniProtKB
Cellular Location
Mitochondrion inner membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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