PTPMT1

PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues.

Full Name

Protein tyrosine phosphatase, mitochondrial 1

Function

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity).
PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity).
Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity).
Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity).
Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).
May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (PubMed:24709986).

Biological Process

Cardiolipin biosynthetic processISS:UniProtKB
Protein dephosphorylationIEA:InterPro
Regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIGI:UniProtKB

Cellular Location

Mitochondrion inner membrane