Mouse Anti-PTPRU Recombinant Antibody (CBT4266) (V2LY-0625-LY1069)

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Tested Data
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Basic Information

Host Animal
Mouse
Clone
CBT4266
Application
WB
Immunogen
Purified recombinant fragment of human PTPRU (AA: extra 579-749) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Protein tyrosine phosphatase, receptor type U
Entrez Gene ID
UniProt ID
Function
Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
Biological Process
Animal organ regenerationIEA:Ensembl
Cell adhesion1 PublicationNAS:UniProtKB
Cell differentiationIEA:UniProtKB-KW
Homotypic cell-cell adhesionIEA:Ensembl
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell-cell adhesion mediated by cadherinManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to cell surfaceManual Assertion Based On ExperimentIDA:UniProtKB
Response to glucocorticoidIEA:Ensembl
Transmembrane receptor protein tyrosine phosphatase signaling pathway1 PublicationNAS:UniProtKB
Cellular Location
Cell junction
Cell membrane
Topology
Extracellular: 19-749
Helical: 750-770
Cytoplasmic: 771-1446
PTM
The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain (By similarity).
In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed.
N-glycosylated.
Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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