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Mouse Anti-PTPRU Recombinant Antibody (CBT4266) (V2LY-0625-LY1069)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4266
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of human PTPRU (AA: extra 579-749) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Protein tyrosine phosphatase, receptor type U
Entrez Gene ID
10076
UniProt ID
Q92729
Function
Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
Biological Process
Animal organ regenerationIEA:Ensembl
Cell adhesion1 PublicationNAS:UniProtKB
Cell differentiationIEA:UniProtKB-KW
Homotypic cell-cell adhesionIEA:Ensembl
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell-cell adhesion mediated by cadherinManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to cell surfaceManual Assertion Based On ExperimentIDA:UniProtKB
Response to glucocorticoidIEA:Ensembl
Transmembrane receptor protein tyrosine phosphatase signaling pathway1 PublicationNAS:UniProtKB
Cellular Location
Cell junction
Cell membrane
Topology
Extracellular: 19-749
Helical: 750-770
Cytoplasmic: 771-1446
PTM
The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain (By similarity).
In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed.
N-glycosylated.
Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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