Mouse Anti-PTPRU Recombinant Antibody (CBYC-P789) (CBMAB-P3495-YC)

Name: Mouse Anti-PTPRU Recombinant Antibody (CBYC-P789)
SKU: CBMAB-P3495-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYC-P789

Application

Immunogen

Mouse myeloma cell line NS0-derived Recombinant human PTP pi/PTPRU, Glu19-Gln740

Specificity

Human, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized from PBS with trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Protein tyrosine phosphatase, receptor type U

Introduction

PTPRU is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion.

Entrez Gene ID

Human	10076
Rat	116680

UniProt ID

Human	Q92729
Rat	F1MAG7

Alternative Names

PTP-RO; R-PTP-PSI; PTP-J; PTPPSI; PTPU2; PCP-2; FMI; PTPRO; R-PTP-U; PTP; PTP-PI; hPTP-J

Function

Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.

Biological Process

Animal organ regenerationIEA:Ensembl
Cell adhesion1 PublicationNAS:UniProtKB
Cell differentiationIEA:UniProtKB-KW
Homotypic cell-cell adhesionIEA:Ensembl
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell-cell adhesion mediated by cadherinManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to cell surfaceManual Assertion Based On ExperimentIDA:UniProtKB
Response to glucocorticoidIEA:Ensembl
Transmembrane receptor protein tyrosine phosphatase signaling pathway1 PublicationNAS:UniProtKB

Cellular Location

Cell junction
Cell membrane

Topology

Extracellular: 19-749
Helical: 750-770
Cytoplasmic: 771-1446

PTM

The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain (By similarity).
In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed.
N-glycosylated.
Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-PTPRU Recombinant Antibody (CBT4266) (CAT#: V2LY-0625-LY1069)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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