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Mouse Anti-PTPRU Recombinant Antibody (CBYC-P789) (CBMAB-P3495-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein tyrosine phosphatase, receptor type U. The antibody can be used for immunoassay techniques, such as WB.
See all PTPRU antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBYC-P789
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived Recombinant human PTP pi/PTPRU, Glu19-Gln740
Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized from PBS with trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein tyrosine phosphatase, receptor type U
Introduction
PTPRU is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion.
Entrez Gene ID
Human10076
Rat116680
UniProt ID
HumanQ92729
RatF1MAG7
Alternative Names
PTP-RO; R-PTP-PSI; PTP-J; PTPPSI; PTPU2; PCP-2; FMI; PTPRO; R-PTP-U; PTP; PTP-PI; hPTP-J
Function
Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
Biological Process
Animal organ regenerationIEA:Ensembl
Cell adhesion1 PublicationNAS:UniProtKB
Cell differentiationIEA:UniProtKB-KW
Homotypic cell-cell adhesionIEA:Ensembl
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell-cell adhesion mediated by cadherinManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to cell surfaceManual Assertion Based On ExperimentIDA:UniProtKB
Response to glucocorticoidIEA:Ensembl
Transmembrane receptor protein tyrosine phosphatase signaling pathway1 PublicationNAS:UniProtKB
Cellular Location
Cell junction
Cell membrane
Topology
Extracellular: 19-749
Helical: 750-770
Cytoplasmic: 771-1446
PTM
The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain (By similarity).
In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed.
N-glycosylated.
Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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