Mouse Anti-PVR Recombinant Antibody (SKII.4) (CBMAB-C12343-LY)

Name: Mouse Anti-PVR Recombinant Antibody (SKII.4)
SKU: CBMAB-C12343-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

SKII.4

Application

Immunogen

Human SK-N-S1 neuroblastoma cells

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Poliovirus Receptor

Entrez Gene ID

5817

UniProt ID

P15151

Alternative Names

Poliovirus Receptor

Function

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.
(Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
(Microbial infection) Acts as a receptor for Pseudorabies virus.
(Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.

Biological Process

Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIBA:GO_Central
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetManual Assertion Based On ExperimentIMP:BHF-UCL
Susceptibility to natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:BHF-UCL
Susceptibility to T cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Isoform Alpha
Cell membrane
Isoform Delta
Cell membrane
Isoform Beta
Secreted
Isoform Gamma
Secreted

Topology

Extracellular: 21-343
Helical: 344-367
Cytoplasmic: 368-417

PTM

N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4.
Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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