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PVR

The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily.

Full Name

Poliovirus Receptor

Function

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.
(Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
(Microbial infection) Acts as a receptor for Pseudorabies virus.
(Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.

Biological Process

Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIBA:GO_Central
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetManual Assertion Based On ExperimentIMP:BHF-UCL
Susceptibility to natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:BHF-UCL
Susceptibility to T cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Isoform Alpha
Cell membrane
Isoform Delta
Cell membrane
Isoform Beta
Secreted
Isoform Gamma
Secreted

Topology

Extracellular: 21-343
Helical: 344-367
Cytoplasmic: 368-417

PTM

N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4.
Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation.

Anti-PVR antibodies

Rabbit Anti-PVR Recombinant Antibody (D3G7H) (CBMAB-N4121-WJ)

SDS

Target: PVR

Host: Rabbit

Specificity: Human, Monkey

Clone: D3G7H

Application*: WB

Rat Anti-PVR Recombinant Antibody (TX21) (CBMAB-C0856-CN)

SDS

Target: PVR

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: TX21

Application*: FC

Mouse Anti-PVR Recombinant Antibody (CBYC-P804) (CBMAB-P3546-YC)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYC-P804

Application*: F, IF

Mouse Anti-PVR Recombinant Antibody (D171) (CBMAB-P3545-YC)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: D171

Application*: F, FN, IF

Mouse Anti-PVR Recombinant Antibody (ANC6A3) (CBMAB-P3544-YC)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: ANC6A3

Application*: E, F

Mouse Anti-PVR Recombinant Antibody (ANC2B2) (CBMAB-P3543-YC)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: ANC2B2

Application*: E, F

Rat Anti-PVR Recombinant Antibody (CBFYA-0055) (CBMAB-X0083-FY)

SDS

Target: PVR

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYA-0055

Application*: F, FN

Mouse Anti-PVR Recombinant Antibody (PV404.19) (CBMAB-C3363-CQ)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: PV404.19

Application*: F

Human Anti-PVR Recombinant Antibody (CBXC-0872) (CBMAB-C1987-CQ)

SDS

Target: PVR

Host: Human

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBXC-0872

Application*: F

Mouse Anti-PVR Recombinant Antibody (CBYY-C2092) (CBMAB-C3530-YY)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBYY-C2092

Application*: E

Rat Anti-PVR Recombinant Antibody (CBYY-C0208) (CBMAB-C0586-YY)

SDS

Target: PVR

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: CBYY-C0208

Application*: F

Mouse Anti-PVR Recombinant Antibody (CBFYC-3072) (CBMAB-C3149-FY)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBFYC-3072

Application*: F, IF

Mouse Anti-PVR Recombinant Antibody (CBFYC-0012) (CBMAB-C0018-FY)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-0012

Application*: F

Rabbit Anti-PVR Recombinant Antibody (CBFYC-3069) (CBMAB-C3146-FY)

SDS

Target: PVR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Rat

Clone: CBFYC-3069

Application*: E

Rabbit Anti-PVR Recombinant Antibody (CBFYC-3070) (CBMAB-C3147-FY)

SDS

Target: PVR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBFYC-3070

Application*: E

Rabbit Anti-PVR Recombinant Antibody (CBFYC-3071) (CBMAB-C3148-FY)

SDS

Target: PVR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-3071

Application*: E, WB, IP

Recombinant Rat Anti-PVR Antibody (CBHb082) (CBMAB-Hb233-LY)

SDS

Target: PVR

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBHb082

Application*: FC, FuncS

Mouse Anti-PVR Recombinant Antibody (2H7CD155) (CBMAB-C12777-LY)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2H7CD155

Application*: F

Rat Anti-PVR Recombinant Antibody (TX56) (CBMAB-C12345-LY)

SDS

Target: PVR

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: TX56

Application*: F

Mouse Anti-PVR Recombinant Antibody (SKII.4) (CBMAB-C12343-LY)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: SKII.4

Application*: F

Rabbit Anti-PVR Recombinant Antibody (D8A5G) (CBMAB-CP1665-LY)

SDS

Target: PVR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D8A5G

Application*: WB, IH, P

Rabbit Anti-PVR Recombinant Antibody (CBR074G) (CBMAB-BT074LY)

SDS

Target: PVR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBR074G

Application*: WB, IHC, ICC

Mouse Anti-PVR Recombinant Antibody (09) (CBMAB-C0102-LY)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 09

Application*: F

Mouse Anti-PVR Recombinant Antibody (300907) (CBMAB-C0926-LY)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 300907

Application*: WB, F, IC, MC

Rabbit Anti-PVR Recombinant Antibody (305) (CBMAB-C0932-LY)

SDS

Target: PVR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: 305

Application*: IF/IC

Rat Anti-PVR Recombinant Antibody (4.24.1) (CBMAB-C1260-LY)

SDS

Target: PVR

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: 4.24.1

Application*: F

Mouse Anti-PVR Recombinant Antibody (0.N.187) (CBMAB-C1399-LY)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Monkey

Clone: 0.N.187

Application*: F, IF

Rabbit Anti-PVR Recombinant Antibody (026) (CBMAB-C1689-LY)

SDS

Target: PVR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Rat

Clone: 026

Application*: E

Rabbit Anti-PVR Recombinant Antibody (1) (CBMAB-C1943-LY)

SDS

Target: PVR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: 1

Application*: E

Rabbit Anti-PVR Recombinant Antibody (114) (CBMAB-C2452-LY)

SDS

Target: PVR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 114

Application*: E, WB, IP

Mouse Anti-PVR Recombinant Antibody (11n42) (CBMAB-C2548-LY)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 11n42

Application*: F

Mouse Anti-PVR Recombinant Antibody (300903) (CBMAB-C5453-LY)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 300903

Application*: WB, IC

Mouse Anti-PVR Recombinant Antibody (4C2B7C10) (CBMAB-C6726-LY)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4C2B7C10

Application*: E, WB

Mouse Anti-PVR Recombinant Antibody (4F10H8A11) (CBMAB-C6908-LY)

SDS

Target: PVR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: 4F10H8A11

Application*: E

Rat Anti-PVR Recombinant Antibody (3F1) (CBMAB-C0326-YY)

SDS

Target: PVR

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 3F1

Application*: F, FN

Rabbit Anti-PVR Recombinant Antibody (501) (CBMAB-C7132-LY)

SDS

Target: PVR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: 501

Application*: E, WB

Rat Anti-PVR Recombinant Antibody (690912) (CBMAB-C7962-LY)

SDS

Target: PVR

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 690912

Application*: WB, F, IC, MC

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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