Sign in or Register   Sign in or Register
  |  

Rat Anti-PVR Recombinant Antibody (TX21) (CBMAB-C0856-CN)

This product is a Rat antibody that recognizes PVR. The antibody TX21 can be used for immunoassay techniques such as: FC.
See all PVR antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
TX21
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Poliovirus Receptor
Introduction
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
5817
UniProt ID
P15151
Alternative Names
PVS; HVED; CD155; NECL5; TAGE4; Necl-5
Function
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.
(Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
(Microbial infection) Acts as a receptor for Pseudorabies virus.
(Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.
Biological Process
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIBA:GO_Central
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetManual Assertion Based On ExperimentIMP:BHF-UCL
Susceptibility to natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:BHF-UCL
Susceptibility to T cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Isoform Alpha
Cell membrane
Isoform Delta
Cell membrane
Isoform Beta
Secreted
Isoform Gamma
Secreted
Topology
Extracellular: 21-343
Helical: 344-367
Cytoplasmic: 368-417
PTM
N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4.
Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-PVR Recombinant Antibody (TX21)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare