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Mouse Anti-PWP1 Recombinant Antibody (2851C5a) (CBMAB-P3549-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2851C5a
Antibody Isotype
IgG2a
Application
Dot

Basic Information

Immunogen
Recombinant human Pwp1 Homolog (S. Cerevisiae) (Pwp1)
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PWP1
Introduction
PWP1 contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocarcinoma.
Entrez Gene ID
11137
UniProt ID
Q13610
Alternative Names
IEF-SSP-9502
Function
Chromatin-associated factor that regulates transcription (PubMed:29065309).
Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309).
Regulates the epigenetic status of rDNA (PubMed:29065309).
Biological Process
Histone H4-K20 trimethylationIEA:Ensembl
Negative regulation of peptidyl-serine phosphorylation of STAT proteinIEA:Ensembl
Positive regulation of stem cell differentiationIEA:Ensembl
Positive regulation of transcription of nucleolar large rRNA by RNA polymerase IManual Assertion Based On ExperimentIDA:FlyBase
rRNA processingIEA:InterPro
Transcription, DNA-templatedManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Nucleus, nucleolus
Chromosome
Associates with chromatin regions of rDNA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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