PWP1

PWP1 contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocarcinoma.
Full Name
PWP1
Function
Chromatin-associated factor that regulates transcription (PubMed:29065309).
Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309).
Regulates the epigenetic status of rDNA (PubMed:29065309).
Biological Process
Histone H4-K20 trimethylationIEA:Ensembl
Negative regulation of peptidyl-serine phosphorylation of STAT proteinIEA:Ensembl
Positive regulation of stem cell differentiationIEA:Ensembl
Positive regulation of transcription of nucleolar large rRNA by RNA polymerase IManual Assertion Based On ExperimentIDA:FlyBase
rRNA processingIEA:InterPro
Transcription, DNA-templatedManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Nucleus, nucleolus
Chromosome
Associates with chromatin regions of rDNA.
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Anti-PWP1 antibodies

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Mouse Anti-PWP1 Recombinant Antibody (3A11) (CBMAB-P3550-YC)

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Target: PWP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3A11
Application*: E, IC, IF, WB
Datasheet SDS

Mouse Anti-PWP1 Recombinant Antibody (2851C5a) (CBMAB-P3549-YC)

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Target: PWP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2851C5a
Application*: DB
Datasheet SDS

Mouse Anti-PWP1 Recombinant Antibody (1A12) (CBMAB-P3548-YC)

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Target: PWP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A12
Application*: E, WB
Datasheet SDS

PWP1 Matched Antibody Pair (948) (APMAB-948LY)

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Target: PWP1
Specificity: Human
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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