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Mouse Anti-QARS Recombinant Antibody (CBLG1-1276) (CBMAB-G3808-LY)

This product is antibody recognizes QARS. The antibody CBLG1-1276 immunoassay techniques such as: ELISA, IHC-P, WB.
See all QARS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-1276
Antibody Isotype
IgG2b
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glutaminyl-TRNA Synthetase
Introduction
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
5859
UniProt ID
P47897
Alternative Names
GLNRS; MSCCA; PRO2195
Function
Glutamine--tRNA ligase (PubMed:26869582).
Plays a critical role in brain development (PubMed:24656866).
Biological Process
Biological Process brain developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process glutaminyl-tRNA aminoacylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:CAFA
Biological Process negative regulation of protein kinase activityManual Assertion Based On ExperimentIDA:CAFA
Biological Process negative regulation of stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:CAFA
Biological Process negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:CAFA
Biological Process tRNA aminoacylation for protein translationTAS:Reactome
Cellular Location
Cytoplasm, cytosol
Cytoplasm
Involvement in disease
Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy (MSCCA):
A severe, autosomal recessive, neurodevelopmental and neurodegenerative disorder characterized by progressive microcephaly, severe seizures in infancy, atrophy of the cerebral cortex and cerebellar vermis, and mild atrophy of the cerebellar hemispheres, resulting in profoundly delayed development and hypotonia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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