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QARS

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Full Name
Glutaminyl-TRNA Synthetase
Function
Glutamine--tRNA ligase (PubMed:26869582).
Plays a critical role in brain development (PubMed:24656866).
Biological Process
Biological Process brain developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process glutaminyl-tRNA aminoacylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:CAFA
Biological Process negative regulation of protein kinase activityManual Assertion Based On ExperimentIDA:CAFA
Biological Process negative regulation of stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:CAFA
Biological Process negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:CAFA
Biological Process tRNA aminoacylation for protein translationTAS:Reactome
Cellular Location
Cytoplasm, cytosol
Cytoplasm
Involvement in disease
Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy (MSCCA):
A severe, autosomal recessive, neurodevelopmental and neurodegenerative disorder characterized by progressive microcephaly, severe seizures in infancy, atrophy of the cerebral cortex and cerebellar vermis, and mild atrophy of the cerebellar hemispheres, resulting in profoundly delayed development and hypotonia.

Anti-QARS antibodies

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Target: QARS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYC3-115
Application*: WB, P
Target: QARS
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 5F5
Application*: E, IH, IP, WB
Target: QARS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-1276
Application*: E, P, WB
Target: QARS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-123
Application*: E, IH, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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