Mouse Anti-QDPR Recombinant Antibody (2D4-1D3) (CBMAB-1821-YC)

Name: Mouse Anti-QDPR Recombinant Antibody (2D4-1D3)
SKU: CBMAB-1821-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2D4-1D3

Application

ELISA

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

quinoid dihydropteridine reductase

Introduction

QDPR is the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. QDPR is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. QDPR is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.

Entrez Gene ID

5860

UniProt ID

P09417

Alternative Names

DHPR; PKU2; SDR33C1

Function

Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.

Biological Process

Biological Process cellular amino acid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process dihydrobiopterin metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process L-phenylalanine catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process tetrahydrobiopterin biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

cytoplasm
cytosol
extracellular exosome

Involvement in disease

Hyperphenylalaninemia, BH4-deficient, C (HPABH4C):
Rare autosomal recessive disorder characterized by hyperphenylalaninemia and severe neurologic symptoms (malignant hyperphenylalaninemia) including axial hypotonia and truncal hypertonia, abnormal thermogenesis, and microcephaly. These signs are attributable to depletion of the neurotransmitters dopamine and serotonin, whose syntheses are controlled by tryptophan and tyrosine hydroxylases that use BH-4 as cofactor. Patients do not respond to phenylalanine-restricted diet. HPABH4C is lethal if untreated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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