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Mouse Anti-QDPR Recombinant Antibody (2D4-1D3) (CBMAB-1821-YC)

Provided herein is a Mouse monoclonal antibody against Human QDPR. The antibody, clone 2D4-1D3, can be used for immunoassay techniques, such as ELISA.
See all QDPR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D4-1D3
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
quinoid dihydropteridine reductase
Introduction
QDPR is the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. QDPR is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. QDPR is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
Entrez Gene ID
5860
UniProt ID
P09417
Alternative Names
DHPR; PKU2; SDR33C1
Function
Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.
Biological Process
Biological Process cellular amino acid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process dihydrobiopterin metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process L-phenylalanine catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process tetrahydrobiopterin biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
cytoplasm
cytosol
extracellular exosome
Involvement in disease
Hyperphenylalaninemia, BH4-deficient, C (HPABH4C):
Rare autosomal recessive disorder characterized by hyperphenylalaninemia and severe neurologic symptoms (malignant hyperphenylalaninemia) including axial hypotonia and truncal hypertonia, abnormal thermogenesis, and microcephaly. These signs are attributable to depletion of the neurotransmitters dopamine and serotonin, whose syntheses are controlled by tryptophan and tyrosine hydroxylases that use BH-4 as cofactor. Patients do not respond to phenylalanine-restricted diet. HPABH4C is lethal if untreated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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