Sign in or Register   Sign in or Register
  |  

Rabbit Anti-QDPR Recombinant Antibody (RB21142) (CBMAB-1834-YC)

Provided herein is a Rabbit monoclonal antibody against Human QDPR. The antibody, clone RB21142, can be used for immunoassay techniques, such as ELISA, WB, IHC.
See all QDPR antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
RB21142
Antibody Isotype
IgG
Application
ELISA, WB, IHC

Basic Information

Immunogen
A KLH conjugated synthetic peptide between 218-243 amino acids from the C-terminal region of human QDPR
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Localized in a.a.218-243

Target

Full Name
quinoid dihydropteridine reductase
Introduction
QDPR is the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. QDPR is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. QDPR is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
Entrez Gene ID
Human5860
Mouse110391
UniProt ID
HumanP09417
MouseQ8BVI4
Alternative Names
DHPR; PKU2; SDR33C1
Function
Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.
Biological Process
Biological Process cellular amino acid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process dihydrobiopterin metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process L-phenylalanine catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process tetrahydrobiopterin biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
cytoplasm
cytosol
extracellular exosome
Involvement in disease
Hyperphenylalaninemia, BH4-deficient, C (HPABH4C):
Rare autosomal recessive disorder characterized by hyperphenylalaninemia and severe neurologic symptoms (malignant hyperphenylalaninemia) including axial hypotonia and truncal hypertonia, abnormal thermogenesis, and microcephaly. These signs are attributable to depletion of the neurotransmitters dopamine and serotonin, whose syntheses are controlled by tryptophan and tyrosine hydroxylases that use BH-4 as cofactor. Patients do not respond to phenylalanine-restricted diet. HPABH4C is lethal if untreated.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-QDPR Recombinant Antibody (RB21142)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare