Mouse Anti-QKI Monoclonal Antibody (2F10) (CBMAB-0022-LY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077).
In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098).
Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
Biological Process mRNA processingIEA:UniProtKB-KW
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process myelinationIEA:Ensembl
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of translationIEA:UniProtKB-KW
Biological Process RNA splicingIEA:UniProtKB-KW
Biological Process spermatid developmentIEA:Ensembl
Biological Process vascular associated smooth muscle cell differentiationIEA:Ensembl
Biological Process vasculogenesisIEA:Ensembl
Cytoplasm
Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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