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Mouse Anti-QKI Monoclonal Antibody (2F10) (CBMAB-0022-LY)

This product is mouse monoclonal antibody recognizes QKI of human. The antibody 2F10 immunoassay techniques such as: ELISA, WB, IP.
See all QKI antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2F10
Antibody Isotype
IgG2c
Application
ELISA, WB. IP

Basic Information

Immunogen
Recombinant peptide (Full Length)
Specificity
Human
Antibody Isotype
IgG2c
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
QKI
Introduction
This gene encodes the RNA binding protein that regulates pre-mRNA splicing, export of mRNAs from the protein translation, nucleus, and mRNA stability. The protein is also involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia.
Entrez Gene ID
9444
UniProt ID
Q96PU8
Alternative Names
QK3
Function
RNA-binding protein that plays a central role in myelinization (PubMed:16641098).
Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077).
In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098).
Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
Biological Process
Biological Process long-chain fatty acid biosynthetic processIEA:Ensembl
Biological Process mRNA processingIEA:UniProtKB-KW
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process myelinationIEA:Ensembl
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of translationIEA:UniProtKB-KW
Biological Process RNA splicingIEA:UniProtKB-KW
Biological Process spermatid developmentIEA:Ensembl
Biological Process vascular associated smooth muscle cell differentiationIEA:Ensembl
Biological Process vasculogenesisIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
PTM
Methylated by PRMT1.
Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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