QKI

QKI is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia.

Full Name

QKI

Function

RNA-binding protein that plays a central role in myelinization (PubMed:16641098).
Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077).
In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098).
Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).

Biological Process

Biological Process long-chain fatty acid biosynthetic processIEA:Ensembl
Biological Process mRNA processingIEA:UniProtKB-KW
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process myelinationIEA:Ensembl
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of translationIEA:UniProtKB-KW
Biological Process RNA splicingIEA:UniProtKB-KW
Biological Process spermatid developmentIEA:Ensembl
Biological Process vascular associated smooth muscle cell differentiationIEA:Ensembl
Biological Process vasculogenesisIEA:Ensembl

Cellular Location

Nucleus
Cytoplasm

PTM

Methylated by PRMT1.
Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).