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Mouse Anti-QPCT Recombinant Antibody (3G2) (CBMAB-1835-YC)

Provided herein is a Mouse monoclonal antibody against Human QPCT. The antibody, clone 3G2, can be used for immunoassay techniques, such as ELISA, IHC-P.
See all QPCT antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G2
Antibody Isotype
IgG2b, κ
Application
ELISA, IHC-P

Basic Information

Immunogen
QPCT (NP_036545, 262 a.a. ~ 360 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
glutaminyl-peptide cyclotransferase
Introduction
QPCT is human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. QPCT is responsible for the biosynthesis of pyroglutamyl peptides and has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue.
Entrez Gene ID
25797
UniProt ID
Q16769
Alternative Names
QC; GCT; sQC
Function
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
Biological Process
Biological Process peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferaseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein modification processManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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