QPCT

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq]
Full Name
glutaminyl-peptide cyclotransferase
Function
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
Biological Process
Biological Process peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferaseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein modification processManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
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Anti-QPCT antibodies

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Mouse Anti-QPCT Recombinant Antibody (CBLG1-2429) (CBMAB-G6518-LY)

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Target: QPCT
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-2429
Application*: SE, P, E
Datasheet SDS

Rabbit Anti-QPCT Recombinant Antibody (RB37104) (CBMAB-01935-YC)

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Target: QPCT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RB37104
Application*: E, WB
Datasheet SDS

Mouse Anti-QPCT Recombinant Antibody (CBYC3-119) (CBMAB-1838-YC)

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Target: QPCT
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYC3-119
Application*: E, IH
Datasheet SDS

Mouse Anti-QPCT Recombinant Antibody (CBYC3-118) (CBMAB-1837-YC)

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Target: QPCT
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYC3-118
Application*: WB
Datasheet SDS

Mouse Anti-QPCT Recombinant Antibody (4E11) (CBMAB-1836-YC)

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Target: QPCT
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 4E11
Application*: WB, IP, E
Datasheet SDS

Mouse Anti-QPCT Recombinant Antibody (3G2) (CBMAB-1835-YC)

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Target: QPCT
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3G2
Application*: E, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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