QPCT

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq]

glutaminyl-peptide cyclotransferase

Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.

Biological Process peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferaseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein modification processManual Assertion Based On ExperimentTAS:ProtInc

Secreted