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QPCT

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq]

Full Name

glutaminyl-peptide cyclotransferase

Function

Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.

Biological Process

Biological Process peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferaseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein modification processManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted

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Anti-QPCT antibodies

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Mouse Anti-QPCT Recombinant Antibody (CBLG1-2429) (CBMAB-G6518-LY)

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Target: QPCT

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBLG1-2429

Application*: SE, P, E

Rabbit Anti-QPCT Recombinant Antibody (RB37104) (CBMAB-01935-YC)

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Target: QPCT

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: RB37104

Application*: E, WB

Mouse Anti-QPCT Recombinant Antibody (CBYC3-119) (CBMAB-1838-YC)

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Target: QPCT

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYC3-119

Application*: E, IH

Mouse Anti-QPCT Recombinant Antibody (CBYC3-118) (CBMAB-1837-YC)

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Target: QPCT

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYC3-118

Application*: WB

Mouse Anti-QPCT Recombinant Antibody (4E11) (CBMAB-1836-YC)

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Target: QPCT

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 4E11

Application*: WB, IP, E

Mouse Anti-QPCT Recombinant Antibody (3G2) (CBMAB-1835-YC)

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Target: QPCT

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3G2

Application*: E, P

Human QPCT ELISA Kit (V2LY-0626-LY4624)

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Target: QPCT

Sensitivity: 0.046 ng/mL

Detection Range: 0.1-40 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Human Recombinant QPCT protein, His Tag (V2LY-0526-LY6430)

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Target: QPCT

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 33-361

Tag: His Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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