Mouse Anti-QSOX1 Recombinant Antibody (1F5C7H) (CBMAB-1857-YC)

Name: Mouse Anti-QSOX1 Recombinant Antibody (1F5C7H)
SKU: CBMAB-1857-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1F5C7H

Application

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

quiescin Q6 sulfhydryl oxidase 1

Introduction

Qsox1 is a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. Qsox1 catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Qsox1 may contribute to disulfide bond formation in a variety of secreted proteins. Qsox1 plays an important role in growth regulation.

Entrez Gene ID

5768

UniProt ID

O00391

Alternative Names

Q6; QSCN6

Function

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277).
Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277).
In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277).

Biological Process

Biological Process extracellular matrix assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of macroautophagyManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein foldingManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Isoform 1
Golgi apparatus membrane
Secreted
A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor.
Isoform 2
Secreted
Found in the extracellular medium of quiescent cells but is not found in proliferating cells.

Topology

Helical: 710-730

PTM

N-glycosylated (PubMed:17331072, PubMed:29757379).
O-glycosylated on Thr and Ser residues (PubMed:29757379).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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