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Mouse Anti-QSOX1 Recombinant Antibody (CBYC3-124) (CBMAB-1858-YC)

Provided herein is a Mouse monoclonal antibody against Human QSOX1. The antibody, clone CBYC3-124, can be used for immunoassay techniques, such as WB, ICC, IHC-P, IHC-Fr, ELISA.
See all QSOX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC3-124
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Quiescin Q6 Sulfhydryl Oxidase 1
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
quiescin Q6 sulfhydryl oxidase 1
Introduction
Qsox1 is a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. Qsox1 catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Qsox1 may contribute to disulfide bond formation in a variety of secreted proteins. Qsox1 plays an important role in growth regulation.
Entrez Gene ID
UniProt ID
Alternative Names
Q6; QSCN6
Function
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277).
Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277).
In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277).
Biological Process
Biological Process extracellular matrix assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of macroautophagyManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 1
Golgi apparatus membrane
Secreted
A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor.
Isoform 2
Secreted
Found in the extracellular medium of quiescent cells but is not found in proliferating cells.
Topology
Helical: 710-730
PTM
N-glycosylated (PubMed:17331072, PubMed:29757379).
O-glycosylated on Thr and Ser residues (PubMed:29757379).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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