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Rabbit Anti-RAB11FIP2 Recombinant Antibody (CBCNR-007) (CBMAB-R0699-CN)

This product is a Rabbit antibody that recognizes RAB11FIP2. The antibody CBCNR-007 can be used for immunoassay techniques such as: WB, IP, FC.
See all RAB11FIP2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBCNR-007
Antibody Isotype
IgG
Application
WB, IP, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
RAB11 Family Interacting Protein 2
Introduction
RAB11FIP2 (RAB11 Family Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Endocytosis and Aquaporin-mediated transport. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and Rab GTPase binding. An important paralog of this gene is RAB11FIP1.
Entrez Gene ID
22841
UniProt ID
Q7L804
Alternative Names
RAB11 Family Interacting Protein 2; RAB11 Family Interacting Protein 2 (Class I); Rab11-FIP2; NRip11; Rab11 Family-Interacting Protein 2; RAB11-FIP2 Long Isoform; KIAA0941;
Function
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics.
Biological Process
Biological Process establishment of cell polarityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process insulin secretion involved in cellular response to glucose stimulusISS:UniProtKB
Biological Process phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulated exocytosisISS:UniProtKB
Biological Process TRAM-dependent toll-like receptor 4 signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell projection, phagocytic cup
Cell membrane
Recycling endosome membrane
Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.
PTM
Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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