RAB11FIP2

RAB11FIP2 (RAB11 Family Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Endocytosis and Aquaporin-mediated transport. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and Rab GTPase binding. An important paralog of this gene is RAB11FIP1.

Full Name

RAB11 Family Interacting Protein 2

Function

A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics.

Biological Process

Biological Process establishment of cell polarityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process insulin secretion involved in cellular response to glucose stimulusISS:UniProtKB
Biological Process phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulated exocytosisISS:UniProtKB
Biological Process TRAM-dependent toll-like receptor 4 signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cell projection, phagocytic cup
Cell membrane
Recycling endosome membrane
Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.

PTM

Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity.