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Mouse Anti-Rab13 Recombinant Antibody (CBT4224) (V2LY-0625-LY362)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4224
Antibody Isotype
IgG1
Application
IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human Rab13 (AA: 66-200) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
RAB13, member RAS oncogene family
Entrez Gene ID
5872
UniProt ID
P51153
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
Biological Process
Biological Process bicellular tight junction assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to insulin stimulusISS:UniProtKB
Biological Process cortical actin cytoskeleton organizationISS:UniProtKB
Biological Process endocytic recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosomal transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endothelial cell chemotaxisISS:UniProtKB
Biological Process establishment of Sertoli cell barrierISS:UniProtKB
Biological Process Golgi vesicle fusion to target membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neuron projection developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein kinase A signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to cell leading edgeIEA:Ensembl
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein secretionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process trans-Golgi network to recycling endosome transportISS:UniProtKB
Biological Process vesicle docking involved in exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Cytoplasmic vesicle membrane
Cell junction, tight junction
Golgi apparatus, trans-Golgi network membrane
Recycling endosome membrane
Cell projection, lamellipodium
Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (PubMed:8294494).
Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (By similarity).
PTM
(Microbial infection) Stearoylated By S.flexneri N-epsilon-fatty acyltransferase IcsB, thereby disrupting the host actin cytoskeleton.
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For research use only. Not intended for any clinical use.

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