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Mouse Anti-RAB18 Recombinant Antibody (1573CT811.119.39) (CBMAB-R0724-CN)

This product is a Mouse antibody that recognizes RAB18. The antibody 1573CT811.119.39 can be used for immunoassay techniques such as: WB.
See all RAB18 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Monkey
Clone
1573CT811.119.39
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.09% Sodium azide

Target

Full Name
RAB18, Member RAS Oncogene Family
Introduction
The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Entrez Gene ID
Human22931
Rat307039
Monkey708843
UniProt ID
HumanQ9NP72
RatQ5EB77
MonkeyF7EUM0
Alternative Names
RAB18, Member RAS Oncogene Family; Ras-Related Protein Rab-18; RAB18 Small GTPase; RAB18LI1; WARBM3;
Function
Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (PubMed:30970241).
Plays a role in apical endocytosis/recycling (By similarity).
Plays a key role in eye and brain development and neurodegeneration (PubMed:21473985).
Biological Process
Biological Process brain developmentISS:UniProtKB
Biological Process endoplasmic reticulum tubular network organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process eye developmentISS:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process lipid droplet organizationManual Assertion Based On ExperimentIMP:MGI
Biological Process small GTPase mediated signal transduction1 PublicationNAS:UniProtKB
Cellular Location
Apical cell membrane
Lipid droplet
Involvement in disease
Warburg micro syndrome 3 (WARBM3):
A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe intellectual disability, spastic diplegia, and hypogonadism.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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