Mouse Anti-RAB18 Recombinant Antibody (1573CT811.119.39) (CBMAB-R0724-CN)

Name: Mouse Anti-RAB18 Recombinant Antibody (1573CT811.119.39)
SKU: CBMAB-R0724-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1573CT811.119.39

Application

Specificity

Human, Rat, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS

Preservative

0.09% Sodium azide

More Infomation

Target

Full Name

RAB18, Member RAS Oncogene Family

Introduction

The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Entrez Gene ID

Human	22931
Rat	307039
Monkey	708843

UniProt ID

Human	Q9NP72
Rat	Q5EB77
Monkey	F7EUM0

Alternative Names

RAB18, Member RAS Oncogene Family; Ras-Related Protein Rab-18; RAB18 Small GTPase; RAB18LI1; WARBM3;

Function

Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (PubMed:30970241).
Plays a role in apical endocytosis/recycling (By similarity).
Plays a key role in eye and brain development and neurodegeneration (PubMed:21473985).

Biological Process

Biological Process brain developmentISS:UniProtKB
Biological Process endoplasmic reticulum tubular network organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process eye developmentISS:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process lipid droplet organizationManual Assertion Based On ExperimentIMP:MGI
Biological Process small GTPase mediated signal transduction1 PublicationNAS:UniProtKB

Cellular Location

Apical cell membrane
Lipid droplet

Involvement in disease

Warburg micro syndrome 3 (WARBM3):
A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe intellectual disability, spastic diplegia, and hypogonadism.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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