Sign in or Register   Sign in or Register
  |  

Mouse Anti-RAB18 Recombinant Antibody (4C8) (CBMAB-R0725-CN)

This product is a Mouse antibody that recognizes RAB18. The antibody 4C8 can be used for immunoassay techniques such as: ELISA.
See all RAB18 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4C8
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa. 1-110 from RAB18 (H15014) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RAB18, Member RAS Oncogene Family
Introduction
The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Entrez Gene ID
22931
UniProt ID
Q9NP72
Alternative Names
RAB18, Member RAS Oncogene Family; Ras-Related Protein Rab-18; RAB18 Small GTPase; RAB18LI1; WARBM3;
Function
Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (PubMed:30970241).
Plays a role in apical endocytosis/recycling (By similarity).
Plays a key role in eye and brain development and neurodegeneration (PubMed:21473985).
Biological Process
Biological Process brain developmentISS:UniProtKB
Biological Process endoplasmic reticulum tubular network organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process eye developmentISS:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process lipid droplet organizationManual Assertion Based On ExperimentIMP:MGI
Biological Process small GTPase mediated signal transduction1 PublicationNAS:UniProtKB
Cellular Location
Apical cell membrane
Lipid droplet
Involvement in disease
Warburg micro syndrome 3 (WARBM3):
A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe intellectual disability, spastic diplegia, and hypogonadism.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-RAB18 Recombinant Antibody (4C8)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare