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Mouse Anti-RAB25 Recombinant Antibody (467657) (CBMAB-R0767-CN)

This product is a Mouse antibody that recognizes RAB25. The antibody 467657 can be used for immunoassay techniques such as: WB.
See all RAB25 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
467657
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human RAB25, Met1-Ala195, Accession # P57735
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
LYOPH
Buffer
PBS, Trehalose
Concentration
LYOPH

Target

Full Name
RAB25, Member RAS Oncogene Family
Introduction
The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015]
Entrez Gene ID
57111
UniProt ID
P57735
Alternative Names
RAB25, Member RAS Oncogene Family; CATX-8; Ras-Related Protein Rab-25; RAB11C; CATX8;
Function
Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226).
Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity).
May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).
Biological Process
Biological Process epithelial cell morphogenesisISS:UniProtKB
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process pseudopodium organizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of vesicle-mediated transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Cell projection, pseudopodium membrane
Cytoplasmic vesicle
Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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