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Mouse Anti-RAB6A Recombinant Antibody (3G3) (CBMAB-R0923-CN)

This product is a Mouse antibody that recognizes RAB6A. The antibody 3G3 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all RAB6A antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
3G3
Antibody Isotype
IgG2b, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 109-208, from human RAB6A (H03617) with GST tag
Specificity
Human, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RAB6A, Member RAS Oncogene Family
Introduction
This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Entrez Gene ID
Human5870
Rat84379
UniProt ID
HumanP20340
RatQ9WVB1
Alternative Names
RAB6A, Member RAS Oncogene Family; RAB6; RAB6, Member RAS Oncogene Family; Ras-Related Protein Rab-6A; Rab GTPase; Rab-6;
Function
Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER (PubMed:25962623).
Biological Process
Biological Process antigen processing and presentationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process early endosome to Golgi transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intra-Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process minus-end-directed organelle transport along microtubuleManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process neuron projection developmentManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process peptidyl-cysteine methylationManual Assertion Based On ExperimentIDA:MGI
Biological Process protein localization to Golgi apparatusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein localization to Golgi membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process retrograde transport, endosome to GolgiManual Assertion Based On ExperimentIBA:GO_Central
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Golgi apparatus membrane
BICD2 facilitates its targeting to Golgi apparatus membrane.
Isoform 1
Golgi apparatus membrane
Isoform 2
Golgi apparatus membrane
PTM
Prenylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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