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Rabbit Anti-RABGEF1 Recombinant Antibody (D21F12) (CBMAB-R0973-CN)

This product is a Rabbit antibody that recognizes RABGEF1. The antibody D21F12 can be used for immunoassay techniques such as: WB, IP.
See all RABGEF1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D21F12
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
RAB Guanine Nucleotide Exchange Factor 1
Introduction
RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]). [supplied by OMIM, Mar 2010]
Entrez Gene ID
Human27342
Mouse56715
Rat360797
UniProt ID
HumanQ9UJ41
MouseQ9JM13
RatG3V631
Alternative Names
RAB Guanine Nucleotide Exchange Factor 1; RAB Guanine Nucleotide Exchange Factor (GEF) 1; Rabaptin-5-Associated Exchange Factor For Rab5; Rabex-5; RABEX5; RAP1; Rab5 GDP/GTP Exchange Factor;
Function
Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).
Biological Process
Biological Process Kit signaling pathwayIEA:Ensembl
Biological Process mast cell degranulationIEA:Ensembl
Biological Process mast cell migrationIEA:Ensembl
Biological Process negative regulation of inflammatory responseIEA:Ensembl
Biological Process negative regulation of interleukin-6 productionIEA:Ensembl
Biological Process negative regulation of Kit signaling pathwayIEA:Ensembl
Biological Process negative regulation of leukocyte migrationIEA:Ensembl
Biological Process negative regulation of mast cell cytokine productionIEA:Ensembl
Biological Process negative regulation of mast cell degranulationIEA:Ensembl
Biological Process negative regulation of protein phosphorylationIEA:Ensembl
Biological Process negative regulation of Ras protein signal transductionIEA:Ensembl
Biological Process negative regulation of receptor-mediated endocytosisIEA:Ensembl
Biological Process protein phosphorylationIEA:Ensembl
Biological Process protein targeting to membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Ras protein signal transductionIEA:Ensembl
Biological Process receptor-mediated endocytosisIEA:Ensembl
Biological Process regulation of Fc receptor mediated stimulatory signaling pathwayIEA:Ensembl
Cellular Location
Cytoplasm
Early endosome
Recycling endosome
PTM
Monoubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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