Rabbit Anti-RABGEF1 Recombinant Antibody (D21F12) (CBMAB-R0973-CN)

Name: Rabbit Anti-RABGEF1 Recombinant Antibody (D21F12)
SKU: CBMAB-R0973-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

D21F12

Application

WB, IP

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

More Infomation

Target

Full Name

RAB Guanine Nucleotide Exchange Factor 1

Introduction

RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]). [supplied by OMIM, Mar 2010]

Entrez Gene ID

Human	27342
Mouse	56715
Rat	360797

UniProt ID

Human	Q9UJ41
Mouse	Q9JM13
Rat	G3V631

Alternative Names

RAB Guanine Nucleotide Exchange Factor 1; RAB Guanine Nucleotide Exchange Factor (GEF) 1; Rabaptin-5-Associated Exchange Factor For Rab5; Rabex-5; RABEX5; RAP1; Rab5 GDP/GTP Exchange Factor;

Function

Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).

Biological Process

Biological Process Kit signaling pathwayIEA:Ensembl
Biological Process mast cell degranulationIEA:Ensembl
Biological Process mast cell migrationIEA:Ensembl
Biological Process negative regulation of inflammatory responseIEA:Ensembl
Biological Process negative regulation of interleukin-6 productionIEA:Ensembl
Biological Process negative regulation of Kit signaling pathwayIEA:Ensembl
Biological Process negative regulation of leukocyte migrationIEA:Ensembl
Biological Process negative regulation of mast cell cytokine productionIEA:Ensembl
Biological Process negative regulation of mast cell degranulationIEA:Ensembl
Biological Process negative regulation of protein phosphorylationIEA:Ensembl
Biological Process negative regulation of Ras protein signal transductionIEA:Ensembl
Biological Process negative regulation of receptor-mediated endocytosisIEA:Ensembl
Biological Process protein phosphorylationIEA:Ensembl
Biological Process protein targeting to membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Ras protein signal transductionIEA:Ensembl
Biological Process receptor-mediated endocytosisIEA:Ensembl
Biological Process regulation of Fc receptor mediated stimulatory signaling pathwayIEA:Ensembl

Cellular Location

Cytoplasm
Early endosome
Recycling endosome

PTM

Monoubiquitinated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Recombinant Mouse Anti-RABGEF1 Recombinant Antibody (G32-11) (CAT#: CBMAB-XB0982-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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