RABGEF1

RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]

Full Name

RAB Guanine Nucleotide Exchange Factor 1

Function

Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).

Biological Process

Biological Process Kit signaling pathwayIEA:Ensembl
Biological Process mast cell degranulationIEA:Ensembl
Biological Process mast cell migrationIEA:Ensembl
Biological Process negative regulation of inflammatory responseIEA:Ensembl
Biological Process negative regulation of interleukin-6 productionIEA:Ensembl
Biological Process negative regulation of Kit signaling pathwayIEA:Ensembl
Biological Process negative regulation of leukocyte migrationIEA:Ensembl
Biological Process negative regulation of mast cell cytokine productionIEA:Ensembl
Biological Process negative regulation of mast cell degranulationIEA:Ensembl
Biological Process negative regulation of protein phosphorylationIEA:Ensembl
Biological Process negative regulation of Ras protein signal transductionIEA:Ensembl
Biological Process negative regulation of receptor-mediated endocytosisIEA:Ensembl
Biological Process protein phosphorylationIEA:Ensembl
Biological Process protein targeting to membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Ras protein signal transductionIEA:Ensembl
Biological Process receptor-mediated endocytosisIEA:Ensembl
Biological Process regulation of Fc receptor mediated stimulatory signaling pathwayIEA:Ensembl

Cellular Location

Cytoplasm
Early endosome
Recycling endosome

PTM

Monoubiquitinated.