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Rat Anti-RALB Recombinant Antibody (399417) (CBMAB-R1222-CN)

This product is a Rat antibody that recognizes RALB. The antibody 399417 can be used for immunoassay techniques such as: WB.
See all RALB antibodies
Published Data
Fig.1 Expression of RalA and RalB by immunohistochemistry in 110 human urothelial bladder tumors in patients treated by radical cystectomy.
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Summary

Host Animal
Rat
Specificity
Human
Clone
399417
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human RalB, Met1-Leu206, Accession # P11234
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
LYOPH
Buffer
PBS, Trehalose
Concentration
LYOPH

Target

Full Name
RAS Like Proto-Oncogene B
Introduction
This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]
Entrez Gene ID
5899
UniProt ID
P11234
Alternative Names
RAS Like Proto-Oncogene B; V-Ral Simian Leukemia Viral Oncogene Homolog B; Ras Related GTP Binding Protein B;
Function
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking (PubMed:10393179, PubMed:17875936, PubMed:18756269).
Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity).
Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity).
Required for suppression of apoptosis (PubMed:17875936).
In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).
Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (PubMed:10393179).
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process cellular response to exogenous dsRNAManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to starvationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of protein bindingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein bindingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein serine/threonine kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of exocyst assemblyISS:UniProtKB
Biological Process regulation of exocyst localizationISS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Midbody
During late cytokinesis, enriched at the midbody.
PTM
Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).
The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of geranylgeranyltransferase I inhibitors, including GGTI-2417.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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