Mouse Anti-RANGRF Recombinant Antibody (CBCNR-184) (CBMAB-R1295-CN)

RAN guanine nucleotide release factor

This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

RAN Guanine Nucleotide Release Factor; Ran-Binding Protein MOG1; RANGNRF; MOG1; MOG1 Homolog (S. Cerevisiae); MOG1 Homolog; HSPC165; HSPC236;

May regulate the intracellular trafficking of RAN (PubMed:11290418).
Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603).
Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603).
Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375).

Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process heart contractionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of protein localization to cell surfaceManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process protein exit from endoplasmic reticulumManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of bundle of His cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of cardiac muscle cell action potential involved in regulation of contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of heart rateManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of membrane depolarizationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of membrane depolarization during cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of membrane potentialManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of microtubule nucleation by Ran protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of sodium ion transmembrane transporter activityManual Assertion Based On ExperimentIDA:BHF-UCL

Nucleus
Cytoplasm, perinuclear region
Cytoplasm
Cell membrane
May shuttle between the nucleus and cytoplasm.