RANGRF

This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants.

Full Name

RAN guanine nucleotide release factor

Function

May regulate the intracellular trafficking of RAN (PubMed:11290418).
Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603).
Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603).
Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375).

Biological Process

Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process heart contractionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of protein localization to cell surfaceManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process protein exit from endoplasmic reticulumManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of bundle of His cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of cardiac muscle cell action potential involved in regulation of contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of heart rateManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of membrane depolarizationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of membrane depolarization during cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of membrane potentialManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of microtubule nucleation by Ran protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of sodium ion transmembrane transporter activityManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Nucleus
Cytoplasm, perinuclear region
Cytoplasm
Cell membrane
May shuttle between the nucleus and cytoplasm.