Sign in or Register   Sign in or Register
  |  

Mouse Anti-RAPGEF1 Recombinant Antibody (3H5) (CBMAB-R1342-CN)

This product is a Mouse antibody that recognizes RAPGEF1. The antibody 3H5 can be used for immunoassay techniques such as: WB, IF.
See all RAPGEF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
3H5
Antibody Isotype
IgG2b
Application
WB, IF

Basic Information

Immunogen
Full length human recombinant protein of human RAPGEF1 (NP_941372) produced in HEK293T cell
Specificity
Human, Monkey
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL

Target

Full Name
Rap guanine nucleotide exchange factor (GEF) 1
Introduction
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human2889
Monkey715272
UniProt ID
HumanQ13905
MonkeyF6XRQ1
Alternative Names
Rap Guanine Nucleotide Exchange Factor 1; Guanine Nucleotide-Releasing Factor 2 (Specific For Crk Proto-Oncogene); Rap Guanine Nucleotide Exchange Factor (GEF) 1; CRK SH3-Binding GNRP; GRF2; Guanine Nucleotide-Releasing Factor 2; Protein C3G; C3G;
Function
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078).
Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.
Biological Process
Biological Process cellular response to cAMPManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to nerve growth factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process nerve growth factor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of neuron projection developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rap protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell junction assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process signal transduction1 PublicationNAS:ProtInc
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Early endosome
PTM
Phosphorylation at Tyr-504 enhances activity as Rap guanine nucleotide exchange factor.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-RAPGEF1 Recombinant Antibody (3H5)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare