RAPGEF1

This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq]
Full Name
Rap guanine nucleotide exchange factor (GEF) 1
Function
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078).
Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.
Biological Process
Biological Process cellular response to cAMPManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to nerve growth factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process nerve growth factor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of neuron projection developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rap protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell junction assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process signal transduction1 PublicationNAS:ProtInc
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Early endosome
PTM
Phosphorylation at Tyr-504 enhances activity as Rap guanine nucleotide exchange factor.
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Anti-RAPGEF1 antibodies

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Mouse Anti-RAPGEF1 Recombinant Antibody (UMAB140) (CBMAB-R1344-CN)

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Target: RAPGEF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: UMAB140
Application*: IH
Datasheet SDS

Mouse Anti-RAPGEF1 Recombinant Antibody (CBCNR-204) (CBMAB-R1343-CN)

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Target: RAPGEF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBCNR-204
Application*: E, WB
Datasheet SDS

Mouse Anti-RAPGEF1 Recombinant Antibody (3H5) (CBMAB-R1342-CN)

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Target: RAPGEF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: 3H5
Application*: WB, IF
Datasheet SDS

Mouse Anti-RAPGEF1 Recombinant Antibody (3D10) (CBMAB-R1341-CN)

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Target: RAPGEF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D10
Application*: E, WB
Datasheet SDS

Mouse Anti-RAPGEF1 Recombinant Antibody (2F5) (CBMAB-R1340-CN)

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Target: RAPGEF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey, Mouse
Clone: 2F5
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-RAPGEF1 Recombinant Antibody (2C3) (CBMAB-R1339-CN)

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Target: RAPGEF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey, Mouse
Clone: 2C3
Application*: WB, IH
Datasheet SDS

Mouse Anti-RAPGEF1 Recombinant Antibody (2B5) (CBMAB-R1338-CN)

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Target: RAPGEF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B5
Application*: WB, IH
Datasheet SDS

Mouse Anti-RAPGEF1 Recombinant Antibody (1F2) (CBMAB-R1337-CN)

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Target: RAPGEF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F2
Application*: WB, IF
Datasheet SDS

Mouse Anti-RAPGEF1 Recombinant Antibody (1B2) (CBMAB-R1336-CN)

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Target: RAPGEF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B2
Application*: WB, IH
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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