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Mouse Anti-RAPGEF6 Recombinant Antibody (CBCNR-155) (CBMAB-R1357-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-155
Antibody Isotype
IgG2a
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.5 mg/mL

Target

Full Name
Rap guanine nucleotide exchange factor (GEF) 6
Introduction
RAPGEF6 (Rap Guanine Nucleotide Exchange Factor 6) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Tight junction. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and GTP-dependent protein binding. An important paralog of this gene is ENSG00000273217.
Entrez Gene ID
51735
UniProt ID
Q8TEU7
Alternative Names
Rap Guanine Nucleotide Exchange Factor 6; PDZ Domain Containing Guanine Nucleotide Exchange Factor (GEF) 2; PDZ Domain-Containing Guanine Nucleotide Exchange Factor 2; Rap Guanine Nucleotide Exchange Factor (GEF) 6; PDZ-GEF2; RA-GEF-2;
Function
Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.
Biological Process
Biological Process microvillus assemblyManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of GTPase activity1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm
Cell membrane
Upon binding to M-Ras, it translocates to the plasma membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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