RAPGEF6

RAPGEF6 (Rap Guanine Nucleotide Exchange Factor 6) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Tight junction. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and GTP-dependent protein binding. An important paralog of this gene is ENSG00000273217.

Rap guanine nucleotide exchange factor (GEF) 6

Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.

Biological Process microvillus assemblyManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of GTPase activity1 PublicationNAS:UniProtKB

Cytoplasm
Cell membrane
Upon binding to M-Ras, it translocates to the plasma membrane.