Mouse Anti-RARG Recombinant Antibody (G-1) (CBMAB-R1407-CN)

Retinoic Acid Receptor Gamma

This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Retinoic Acid Receptor Gamma; Nuclear Receptor Subfamily 1 Group B Member 3; RAR-Gamma; NR1B3; Retinoic Acid Nuclear Receptor Gamma Variant 1; Retinoic Acid Nuclear Receptor Gamma Variant 2; Retinoic Acid Receptor, Gamma; RARC;

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Biological Process anterior/posterior pattern specificationIEA:Ensembl
Biological Process apoptotic processIEA:Ensembl
Biological Process canonical Wnt signaling pathwayManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process cellular response to retinoic acidIEA:Ensembl
Biological Process embryonic camera-type eye developmentIEA:Ensembl
Biological Process embryonic eye morphogenesisISS:BHF-UCL
Biological Process embryonic hindlimb morphogenesisISS:BHF-UCL
Biological Process face developmentIEA:Ensembl
Biological Process glandular epithelial cell developmentIEA:Ensembl
Biological Process growth plate cartilage chondrocyte growthIEA:Ensembl
Biological Process Harderian gland developmentIEA:Ensembl
Biological Process hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process multicellular organism growthIEA:Ensembl
Biological Process negative regulation of cell population proliferationISS:BHF-UCL
Biological Process negative regulation of chondrocyte differentiationIEA:Ensembl
Biological Process negative regulation of stem cell proliferationIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIISS:BHF-UCL
Biological Process neural tube closureIEA:Ensembl
Biological Process positive regulation of apoptotic processISS:BHF-UCL
Biological Process positive regulation of cell population proliferationIEA:Ensembl
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process positive regulation of programmed cell deathISS:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIISS:BHF-UCL
Biological Process prostate gland epithelium morphogenesisIEA:Ensembl
Biological Process regulation of cell sizeManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of myelinationIEA:Ensembl
Biological Process regulation of myeloid cell differentiationIEA:Ensembl
Biological Process response to retinoic acidManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process retinoic acid receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process stem cell proliferationIEA:Ensembl
Biological Process trachea cartilage developmentIEA:Ensembl

Nucleus
Cytoplasm