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Mouse Anti-RARRES3 Recombinant Antibody (CBCNR-228) (CBMAB-R1444-CN)

This product is a Mouse antibody that recognizes RARRES3. The antibody CBCNR-228 can be used for immunoassay techniques such as: WB, ELISA, IHC-P, FC.
See all RARRES3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-228
Antibody Isotype
IgG2a
Application
WB, ELISA, IHC-P, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
retinoic acid receptor responder (tazarotene induced) 3
Introduction
Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]
Entrez Gene ID
5920
UniProt ID
Q9UL19
Alternative Names
Retinoic Acid Receptor Responder 3; Retinoic Acid Receptor Responder (Tazarotene Induced) 3; Retinoid-Inducible Gene 1 Protein; Tazarotene-Induced Gene 3 Protein; RAR-Responsive Protein TIG3; HRAS-Like Suppressor 4; HRSL4; RIG1;
Function
Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625).
Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852).
For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464).
Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464).
Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852).
Promotes keratinocyte differentiation via activation of TGM1 (PubMed:17762858).
Biological Process
Biological Process lipid catabolic processIEA:UniProtKB-KW
Biological Process N-acylphosphatidylethanolamine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process phosphatidylethanolamine acyl-chain remodelingTAS:Reactome
Biological Process phospholipid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of keratinocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein-glutamine gamma-glutamyltransferase activityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane
Topology
Cytoplasmic: 1-134
Helical: 135-155
Lumenal: 156-164
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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