RARRES3

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq]

Full Name

retinoic acid receptor responder (tazarotene induced) 3

Function

Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625).
Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852).
For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464).
Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464).
Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852).
Promotes keratinocyte differentiation via activation of TGM1 (PubMed:17762858).

Biological Process

Biological Process lipid catabolic processIEA:UniProtKB-KW
Biological Process N-acylphosphatidylethanolamine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process phosphatidylethanolamine acyl-chain remodelingTAS:Reactome
Biological Process phospholipid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of keratinocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein-glutamine gamma-glutamyltransferase activityManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Membrane

Topology

Cytoplasmic: 1-134
Helical: 135-155
Lumenal: 156-164