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Mouse Anti-RASD1 Recombinant Antibody (2D12) (CBMAB-R1470-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2D12
Antibody Isotype
IgG2a, κ
Application
ELISA, IF

Basic Information

Immunogen
Partial recombinant corresponding to aa. 1-110, from human RASD1 (H18041, 51655) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RAS, dexamethasone-induced 1
Introduction
This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Entrez Gene ID
51655
UniProt ID
Q9Y272
Alternative Names
Ras Related Dexamethasone Induced 1; Dexamethasone-Induced Ras-Related Protein 1; Activator Of G-Protein Signaling 1; RAS, Dexamethasone-Induced 1; Ras-Related Protein; DEXRAS1; AGS1; Activator Of G Protein Signaling; MGC:26290;
Function
Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).
Biological Process
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of transcription, DNA-templatedIEA:Ensembl
Biological Process nitric oxide mediated signal transductionIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Cytoplasm, perinuclear region
Nucleus
PTM
S-nitrosylation stimulates guanine-nucleotide exchange activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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