Mouse Anti-RASD1 Recombinant Antibody (2D12) (CBMAB-R1470-CN)

Name: Mouse Anti-RASD1 Recombinant Antibody (2D12)
SKU: CBMAB-R1470-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2D12

Application

ELISA, IF

Immunogen

Partial recombinant corresponding to aa. 1-110, from human RASD1 (H18041, 51655) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

RAS, dexamethasone-induced 1

Introduction

This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Entrez Gene ID

51655

UniProt ID

Q9Y272

Alternative Names

Ras Related Dexamethasone Induced 1; Dexamethasone-Induced Ras-Related Protein 1; Activator Of G-Protein Signaling 1; RAS, Dexamethasone-Induced 1; Ras-Related Protein; DEXRAS1; AGS1; Activator Of G Protein Signaling; MGC:26290;

Function

Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).

Biological Process

Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of transcription, DNA-templatedIEA:Ensembl
Biological Process nitric oxide mediated signal transductionIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane
Cytoplasm, perinuclear region
Nucleus

PTM

S-nitrosylation stimulates guanine-nucleotide exchange activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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