RASD1

This gene encodes a Ras-related protein that is stimulated by dexamethasone. The exact function of this gene is unknown, but it may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. In addition, studies of a similar rat protein suggest that it functions as as a novel physiologic nitric oxide (NO) effector. The gene product belongs to the Ras superfamily of small GTPases. [provided by RefSeq]

Full Name

RAS, dexamethasone-induced 1

Function

Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).

Biological Process

Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of transcription, DNA-templatedIEA:Ensembl
Biological Process nitric oxide mediated signal transductionIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane
Cytoplasm, perinuclear region
Nucleus

PTM

S-nitrosylation stimulates guanine-nucleotide exchange activity.